1. What difference exists between the compaction of chromosomes during metaphase and interphase? Give at least one reason why this difference may be necessary.
2. What is the role of the core histones in compaction as compared to the role of histone H1?
3. Indicate which of the four major classes of rearrangements (deletions, duplications, inversions, and translocations) are most likely to be associated with each of the following phenomena. In each case, explain the effect.
a.) semisterility
b.) lethality
c.) vulnerability to mutation
d.) altered genetic map
e.) haploinsufficiency
f.) neomorphic mutation
g.) hypermorphic mutation
h.) crossover suppression
i.) aneuploidy