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The Nullification Crisis of 1832-1833 was a political and constitutional crisis that occurred in the United States when the state of South Carolina refused to abide by federal tariff laws, claiming it had the right to nullify federal laws it deemed unconstitutional. The crisis illustrated the deep divide between the North and South, as it pitted the interests of Southern states, who depended on agriculture and foreign trade, against the interests of Northern states, who favored high tariffs to protect their manufacturing industries. South Carolina, led by Vice President John C. Calhoun, argued that the federal government had overstepped its constitutional authority with the Tariff of 1828, also known as the “Tariff of Abominations,” and threatened to secede from the Union if the federal government tried to enforce the tariff. President Andrew Jackson, a Southerner himself, responded forcefully to South Carolina’s challenge to federal authority, stating that nullification was unconstitutional and tantamount to treason. The significance of the Nullification Crisis can be compared to that of the Missouri Compromise of 1820, which sought to resolve the question of slavery in new territories. The Missouri Compromise prohibited slavery north of the 36°30′ parallel, except for Missouri, which was admitted to the Union as a slave state. The compromise temporarily resolved the issue of slavery in the territories, but it also highlighted the growing sectional tensions between the North and South over the issue of slavery. The Nullification Crisis and the Missouri Compromise were pivotal moments in American history that revealed the deep political, economic, and ideological divisions between the North and South. While the Missouri Compromise sought to address the question of slavery, the Nullification Crisis revealed a fundamental disagreement over the role of the federal government and states’ rights. Ultimately, both crises foreshadowed the coming Civil War and underscored the challenges of maintaining a unified nation that could accommodate the diverse interests and values of its citizens.